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JCIMPT: Joint Center for Innovative Membrane Protein Technologies

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JCIMPT: Joint Center for Innovative Membrane Protein Technologies
2008 GPCR Docking Assessment
RMI Nov 2007 Meeting
About JCIMPT
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Mission:

The mission of the Joint Center for Innovative Membrane Protein Technologies (JCIMPT) is to develop and disseminate methods and technologies for structure-grade production of integral membrane proteins. Miniaturization and automation are major components in the systematic investigation of membrane proteins and in the development of novel genetically engineered expression systems and sample preparation technologies. The structure of the JCIMPT includes three primary projects: Membrane Protein Expression; Membrane Protein Stabilization;and Membrane Protein Biophysical Analysis.

 

 JCIMPT Recent Publications
Sort by AttachmentsUse SHIFT+ENTER to open the menu (new window).
Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structureUse SHIFT+ENTER to open the menu (new window).
Roth CB, Hanson MA, Stevens RCJ Mol Biol 3761305-13192008PMID:18222471
Microscale fluorescent thermal stability assay for membrane proteins.Use SHIFT+ENTER to open the menu (new window).
Alexandrov AI, Mileni M, Chien EY, Hanson MA, Stevens RCStructure16351-3592008PMID:18334210
A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptorUse SHIFT+ENTER to open the menu (new window).
M.A. Hanson, V. Cherezov, C.B. Roth, M.T. Griffith, V.-P. Jaakola, E.Y.T. Chien, J. Velasquez, P. Kuhn, R.C. Stevens Structure16897-9052008DOI:10.1016/j.str.2008.05.001
Microscale NMR screening of new detergents for membrane protein structural biologyUse SHIFT+ENTER to open the menu (new window).
Q. Zhang, R. Horst, M. Geralt, X. Ma, W.X. Hong, M.G. Finn, R.C. Stevens, K. Wüthrich J. Am. Chem. Soc.  1307357-7363 2008DOI:10.1021/ja077863d
Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomicsUse SHIFT+ENTER to open the menu (new window).
J.D. Ng, R.C. Stevens, P. Kuhn Methods Mol. Biol.426363-376 2008DOI:10.1007/978-1-60327-058-8
In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannelsUse SHIFT+ENTER to open the menu (new window).
J.D. Ng, P.J. Clark, R.C. Stevens, P. Kuhn Acta Crystallogr D 64189-197  2008
Designing facial amphiphiles for the stabilization of integral membrane proteinsUse SHIFT+ENTER to open the menu (new window).
Zhang Q, Ma X, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG, Chang GAngew Chem Int Ed Engl467023-70252007PMID:17691085
Flexibility in the ABC transporter MsbA: Alternating access with a twistUse SHIFT+ENTER to open the menu (new window).
Ward A, Reyes CL, Yu J, Roth CB, Chang GProc Natl Acad Sci U S A10419005-190102007PMID:18024585
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor functionUse SHIFT+ENTER to open the menu (new window).
Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, et al.Science3181266-12732007PMID:17962519
Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expressionUse SHIFT+ENTER to open the menu (new window).
Hanson MA, Brooun A, Baker KA, Jaakola VP, Roth C, Chien EY, Alexandrov A, Velasquez J, Davis L, Griffith M, et al.Protein Expr Purif 5685-922007PMID:17723307
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.Use SHIFT+ENTER to open the menu (new window).
Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, et al.Science3181258-1265.2007PMID:17962520
X-ray structure of EmrE supports dual topology model.Use SHIFT+ENTER to open the menu (new window).
Chen YJ, Pornillos O, Lieu S, Ma C, Chen AP, Chang GProc Natl Acad Sci U S A 10418999-190042007PMID:18024586

 News and Views
2008 GPCR Docking Assessment Now OpenUse SHIFT+ENTER to open the menu (new window).
8/19/2008http://jcimpt.scripps.edu/GPCRDock/default.aspx
RFA for RoadMap Initiative on Membrane Protein Production for Structure DeterminationUse SHIFT+ENTER to open the menu (new window).
6/24/2008RFA for Centers on Membrane Protein Production
Next phase (2009-2013) NIH Structural Biology Roadmap Initiative - AnnouncedUse SHIFT+ENTER to open the menu (new window).
4/1/2008http://nihroadmap.nih.gov/structuralbiology/
Publication list has been updatedUse SHIFT+ENTER to open the menu (new window).
3/27/2008http://jcimpt.scripps.edu/Pages/publications.aspx
Roadmap Meeting Presentations Added 01/07/2008Use SHIFT+ENTER to open the menu (new window).
1/7/2008Roadmap Meeting Presentations
Roadmap Meeting site updated 7/30/07Use SHIFT+ENTER to open the menu (new window).
7/30/2007
Updated Schedule Available for the November 2007 NIH Roadmap Membrane Protein Meeting Use SHIFT+ENTER to open the menu (new window).
5/18/2007
JCIMPT to host the first NIH Roadmap Membrane Protein Production and Technologies MeetingUse SHIFT+ENTER to open the menu (new window).
2/3/2007

 beta-2-Adrenergic Receptor - see Cherezov et al.

  		 
NIH Roadmap

 Membrane Protein Centers
RikenUse SHIFT+ENTER to open the menu (new window).
http://www.riken.go.jp/engn/
European Membrane Protein Consortium (E-Mep)Use SHIFT+ENTER to open the menu (new window).
http://www.e-mep.org/
Membrane Protein Expression Center (MPEC)Use SHIFT+ENTER to open the menu (new window).
http://mpec.ucsf.edu/index.htm
Joint Center for Innovative Membrane Protein Technologies (JCIMPT)Use SHIFT+ENTER to open the menu (new window).
http://jcimpt.scripps.edu/
Center for Structures of Membrane Proteins (CSMP)Use SHIFT+ENTER to open the menu (new window).
http://csmp.ucsf.edu/index.htm
New York Consortium on Membrane Protein Structure (NYCOMPS)Use SHIFT+ENTER to open the menu (new window).
http://www.nycomps.org